Ruth B Caldwell Selected Research

Arginase

1/2022	Preclinical investigation of Pegylated arginase 1 as a treatment for retina and brain injury.
11/2021	Endothelial arginase 2 mediates retinal ischemia/reperfusion injury by inducing mitochondrial dysfunction.
1/2021	Deletion of arginase 2 attenuates neuroinflammation in an experimental model of optic neuritis.
2/2020	Is the Arginase Pathway a Novel Therapeutic Avenue for Diabetic Retinopathy?
1/2020	Role of Arginase 2 in Murine Retinopathy Associated with Western Diet-Induced Obesity.
1/2020	Arginase Pathway in Acute Retina and Brain Injury: Therapeutic Opportunities and Unexplored Avenues.
12/2019	Deletion of Arginase 2 Ameliorates Retinal Neurodegeneration in a Mouse Model of Multiple Sclerosis.
3/2019	Role of Arginase 2 in Systemic Metabolic Activity and Adipose Tissue Fatty Acid Metabolism in Diet-Induced Obese Mice.
2/2019	Hyperglycemia-impaired aortic vasorelaxation mediated through arginase elevation: Role of stress kinase pathways.
1/2019	Mechanisms of obesity-induced metabolic and vascular dysfunctions.

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Ruth B Caldwell Research Topics

Disease

16	Inflammation (Inflammations) 01/2021 - 01/2006
14	Diabetic Retinopathy (Retinopathy, Diabetic) 01/2022 - 11/2003
13	Ischemia 01/2022 - 08/2005
10	Pathologic Neovascularization 11/2022 - 04/2003
9	Hyperoxia 01/2018 - 02/2002
8	Hyperglycemia 01/2022 - 11/2005
8	Hypoxia (Hypoxemia) 01/2022 - 08/2005
8	Cardiovascular Diseases (Cardiovascular Disease) 02/2020 - 11/2006
8	Fibrosis (Cirrhosis) 11/2017 - 02/2010
7	Reperfusion Injury 11/2021 - 09/2006
7	Retinal Neovascularization 01/2018 - 10/2003
6	Retinopathy of Prematurity (Retrolental Fibroplasia) 01/2018 - 01/2011
5	Obesity 01/2020 - 11/2017
5	Neoplasms (Cancer) 01/2018 - 11/2005
4	Hypertension (High Blood Pressure) 11/2017 - 11/2006
4	Ganglion Cysts (Ganglion) 11/2016 - 11/2003
4	Erectile Dysfunction 06/2013 - 12/2010
4	Leukostasis 01/2013 - 07/2008
3	Retinal Diseases 01/2018 - 12/2002
3	Body Weight (Weight, Body) 01/2018 - 11/2017
3	Blindness (Hysterical Blindness) 11/2016 - 10/2009
3	Glaucoma 11/2016 - 11/2003
3	Vascular System Injuries 01/2014 - 10/2003
2	Optic Nerve Injuries 01/2022 - 01/2018
2	Brain Injuries (Brain Injury) 01/2022 - 01/2020
2	Mitochondrial Diseases (Mitochondrial Disease) 11/2021 - 01/2019
2	Multiple Sclerosis 01/2020 - 12/2019
2	Vascular Diseases (Vascular Disease) 03/2015 - 03/2010
2	Edema (Dropsy) 09/2013 - 10/2012
2	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 03/2013 - 01/2013
2	Uveitis 08/2009 - 06/2009
2	Diabetic Angiopathies (Diabetic Angiopathy) 11/2006 - 11/2005
2	Atherosclerosis 11/2006 - 11/2005
2	Proliferative Vitreoretinopathy 12/2002 - 12/2002
1	Choroidal Neovascularization 11/2022
1	Brain Ischemia (Cerebral Ischemia) 01/2022
1	Brain Infarction 01/2022
1	Hyperlipidemias (Hyperlipidemia) 01/2022
1	Macular Edema 01/2022
1	Middle Cerebral Artery Infarction (Middle Cerebral Artery Syndrome) 01/2022
1	Cardiotoxicity 01/2021
1	Cardiomegaly (Heart Hypertrophy) 01/2021
1	Optic Neuritis (Retrobulbar Neuritis) 01/2021
1	Neuroinflammatory Diseases 01/2021
1	Stroke (Strokes) 02/2020
1	Central Nervous System Diseases (CNS Diseases) 02/2020
1	Brain Diseases (Brain Disorder) 01/2020

Drug/Important Bio-Agent (IBA)

36	ArginaseIBA 01/2022 - 08/2009
35	Retinaldehyde (Retinal)IBA 01/2022 - 02/2002
18	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2018 - 04/2003
15	Oxygen (Dioxygen)IBA 11/2021 - 02/2002
9	Nitric Oxide (Nitrogen Monoxide)FDA Link 11/2017 - 09/2003
7	Protein Isoforms (Isoforms)IBA 01/2020 - 01/2013
7	Proteins (Proteins, Gene)FDA Link 01/2018 - 09/2006
6	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2022 - 11/2005
6	EnzymesIBA 02/2020 - 07/2008
6	CollagenIBA 03/2019 - 06/2011
6	Arginine (L-Arginine)FDA Link 11/2017 - 11/2006
6	NADPH Oxidases (NAD(P)H oxidase)IBA 10/2011 - 08/2005
5	Angiotensin IIIBA 01/2015 - 03/2010
5	Nitric Oxide Synthase (NO Synthase)IBA 01/2015 - 10/2003
4	Phosphotransferases (Kinase)IBA 11/2022 - 12/2002
3	Peroxynitrous Acid (Peroxynitrite)IBA 01/2014 - 09/2003
3	Streptozocin (Streptozotocin)FDA Link 01/2013 - 09/2006
2	Glucose (Dextrose)FDA LinkGeneric 01/2022 - 11/2021
2	Pharmaceutical PreparationsIBA 01/2021 - 04/2012
2	Saline SolutionIBA 01/2018 - 01/2016
2	OrnithineIBA 01/2018 - 11/2017
2	Blood Glucose (Blood Sugar)IBA 11/2017 - 11/2017
2	PolyaminesIBA 11/2017 - 02/2010
2	Proline (L-Proline)FDA Link 11/2017 - 02/2010
2	AcidsIBA 11/2017 - 01/2014
2	Purinergic P1 Receptors (Adenosine Receptor)IBA 01/2017 - 05/2011
2	Neuroprotective AgentsIBA 01/2016 - 01/2007
2	AntioxidantsIBA 05/2014 - 07/2008
2	Nitric Oxide Synthase Type III (Endothelial Nitric Oxide Synthase)IBA 01/2014 - 09/2006
2	rho-Associated KinasesIBA 06/2013 - 06/2011
2	CitrullineIBA 01/2013 - 11/2006
2	AlbuminsIBA 01/2013 - 05/2011
2	Therapeutic UsesIBA 08/2011 - 11/2006
2	p38 Mitogen-Activated Protein KinasesIBA 12/2010 - 01/2006
2	CytokinesIBA 03/2010 - 06/2009
2	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 10/2009 - 07/2008
2	LipopolysaccharidesIBA 08/2009 - 06/2009
2	acetovanillone (apocynin)IBA 07/2008 - 08/2005
2	Caspase 3 (Caspase-3)IBA 09/2006 - 09/2003
2	Superoxides (Superoxide)IBA 08/2005 - 09/2003
2	Retinal Pigments (Pigments, Visual)IBA 12/2002 - 12/2002
1	Phosphoric Monoester Hydrolases (Phosphatases)IBA 11/2022
1	Polyethylene Glycols (Polyethylene Glycol)FDA LinkGeneric 01/2022
1	ChloridesIBA 01/2022
1	PC6 extract (PC6)IBA 01/2021
1	Doxorubicin (Adriamycin)FDA LinkGeneric 01/2021
1	InflammasomesIBA 01/2020
1	FructoseIBA 01/2020

Therapy/Procedure

13	Therapeutics 01/2022 - 11/2003
3	Lasers (Laser) 11/2022 - 06/2005
3	Intraperitoneal Injections 01/2022 - 01/2016
2	Light Coagulation 09/2013 - 06/2005
1	Electroacupuncture 01/2021